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DURECT's DURIN® biodegradable implant technology is a platform for short- and long-term parenteral drug delivery lasting in duration from weeks to six months. The technology is based on the use of biodegradable polymer excipients, which have a proven record of safety and effectiveness in approved drug delivery and medical device products.

DURECT's DURIN® biodegradable implant technology is a platform for short- and long-term parenteral drug delivery lasting in duration from weeks to six months. The technology is based on the use of biodegradable polymer excipients, which have a proven record of safety and effectiveness in approved drug delivery and medical device products.
DURECT's DURIN® biodegradable implant technology is a platform for short- and long-term parenteral drug delivery lasting in duration from weeks to six months. The technology is based on the use of biodegradable polymer excipients, which have a proven record of safety and effectiveness in approved drug delivery and medical device products.




Our work in the development of drug-loaded implants for controlled release spans more than 20 years and we have developed a proprietary drug delivery platform that can deliver active agents from a few weeks to several months, and where the release profile can be tailored for continuous or delayed release. This technology involves incorporating active compounds in polymeric delivery systems to provide extended release of the active agent. We work with both biodegradable and non-biodegradable polymers and have developed formulations for a broad range of actives including peptides and proteins. Our experience includes manufacture of biodegradable excipients, formulation and process development, and cGMP production of clinical supplies.

Drug-loaded implants consist of a mixture of an active and a polymeric excipient formed into a fiber, rod, film or other shape. The implant may be a simple monolithic mixture or may incorporate a rate-controlling membrane. Drug release is controlled by a number of variables including drug content, polymer composition and molecular weight, device geometry, and manufacturing process. DURECT’S drug-loaded implants offer many advantages for long-term delivery of active ingredients.

Sustained, delayed, and zero-order release profiles
Delivery times from weeks to months
Avoidance of solvents during processing
100% solids and high drug contents provide highest payloads possible
Local and systemic delivery
Robust manufacturing processes
Extensive clinical experience
Ability to custom make polymers

We typically work with biodegradable polymers to eliminate the need for device removal following therapy.

To request additional information on DURIN Biodegradable Implants, please download the DURIN® Fact Sheet (.PDF).

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Last updated: June 27, 2014
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