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DURECT Corporation Presenting at the First Annual Merriman Curhan Ford & Co. Investor Summit

Cupertino, CA-

September 16, 2004

DURECT Corporation (NASDAQ: DRRX) announced today that it will present at the First Annual Merriman Curhan Ford & Co. Investor Summit. The conference is being held at The Mark Hopkins Hotel in San Francisco, CA. Dr. James E. Brown, President and Chief Executive Officer, will be presenting at the conference on Monday, September 20, 2004 at 10:45 a.m. Pacific Time.

A live audio webcast of the presentation will be available by accessing DURECT’s homepage at http://www.durect.com and clicking “Investor Relations”.

DURECT Corporation (www.durect.com) is pioneering the development and commercialization of pharmaceutical systems for the treatment of chronic debilitating diseases and enabling biotechnology-based pharmaceutical products. DURECT's goal is to deliver the right drug to the right site in the right amount at the right time.

CONTACT:
Schond L. Greenway, Executive Director, Investor Relations and Strategic Planning of DURECT Corporation
Phone: +1-408-777-1417

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