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DURECT Corporation Invites You to Join Its Fourth Quarter 2007 Earnings Conference Call

CUPERTINO, CA-

January 31, 2008

In conjunction with DURECT Corporation's (Nasdaq: DRRX) fourth quarter 2007 financial results press release, you are invited to listen to the conference call that will be broadcast live over the Internet on Wednesday, February 6, 2008 at 9:00 a.m. EST (6:00 a.m. PST).

When:     Wednesday, February 6, 2008 at 9:00 a.m. EST (6:00 a.m. PST).
Where:     Live over the Internet - Simply log on to www.durect.com, and then click 'Investor Relations' and then 'Events Calendar.'
Webcast Link:     http://phx.corporate-ir.net/phoenix.zhtml?c=121590&p=irol-calendar

If you are unable to participate during the live webcast, the call will be archived on DURECT's website under Audio Archive in the "Investor Relations" section.

About DURECT Corporation
DURECT Corporation is an emerging specialty pharmaceutical company developing pharmaceutical systems based on its proprietary drug delivery platform technologies. The Company currently has a number of late-stage pharmaceutical products in development addressing large markets in pain management, with a number of research programs underway targeting chronic disease and other therapeutic areas. For more information, please visit www.durect.com.

SOURCE: DURECT Corporation
CONTACT: Matthew J. Hogan, Chief Financial Officer, +1-408-777-4936

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