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DURECT to Participate in Susquehanna Financial Healthcare Conference

Cupertino, CA-

February 29, 2008

DURECT Corporation (NASDAQ: DRRX) announced today that James Brown, President and Chief Executive Officer, will be presenting at the SIGnificant Investment Options in Healthcare conference hosted by Susquehanna Financial Group on Tuesday, March 4, 2008 at 2:45 p.m. EST. The conference is being held at the W Hotel, 541 Lexington Avenue, New York City.

About DURECT Corporation
DURECT Corporation is an emerging specialty pharmaceutical company developing pharmaceutical systems based on its proprietary drug delivery platform technologies. The Company currently has a number of late-stage pharmaceutical products in development addressing large markets in pain management, with a number of research programs underway targeting chronic disease and other therapeutic areas. For more information, please visitwww.durect.com.

SOURCE:    DURECT Corporation
CONTACT: Matthew J. Hogan, Chief Financial Officer, +1-408-777-4936

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