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Date Title   11/03/08 DURECT Corporation Announces Third Quarter 2008 Financial Results 10/29/08 DURECT's Collaboration With Alpharma Clears HSR Review and Is Effective 10/28/08 DURECT Corporation to Participate in Upcoming Healthcare Conferences 10/27/08 DURECT Corporation Invites You to Join Its Third Quarter 2008 Earnings Conference Call 09/22/08 Alpharma to Develop and Commercialize DURECT's ELADUR(TM) Pain Patch 09/15/08 DURECT Corporation Presenting at the 2008 UBS Global Life Sciences Conference 08/27/08 DURECT Announces the IND Submission for a Third Abuse-Resistant Opioid Pain Medication Based on Its ORADUR(TM) Technology 08/12/08 REMOXY(R) NDA Filing Accepted by FDA and Priority Review Granted 08/05/08 DURECT Corporation Announces Second Quarter 2008 Financial Results 07/30/08 DURECT Corporation Invites You to Join Its Second Quarter 2008 Earnings Conference Call 06/30/08 ELADUR(TM) Development Update: DURECT Receives Orphan Drug Designation for Bupivacaine for Post-Herpetic Neuralgia 06/17/08 DURECT's Convertible Notes Exchange into Equity at Maturity 06/10/08 New Drug Application Submitted for Remoxy(TM) (ORADUR(TM)-Based Oxycodone) 06/06/08 DURECT Corporation to Participate in Upcoming Healthcare Conferences 05/21/08 DURECT Corporation Presenting at the 2008 UBS Global Generic and Specialty Pharmaceuticals Conference 05/07/08 DURECT Corporation Announces First Quarter 2008 Financial Results 04/29/08 DURECT Corporation Invites You to Join Its First Quarter 2008 Earnings Conference Call 04/22/08 DURECT to Participate in Morgan Stanley Global Healthcare Conference 04/07/08 DURECT Provides Update on CHRONOGESIC(R) Research Program 03/11/08 DURECT to Participate in Cowen Annual Healthcare Conference 02/29/08 DURECT to Participate in Susquehanna Financial Healthcare Conference 02/05/08 DURECT Corporation Announces Fourth Quarter and Year End 2007 Financial Results 02/04/08 DURECT to Present at BIO CEO Investor Conference 2008 01/31/08 DURECT Corporation Invites You to Join Its Fourth Quarter 2007 Earnings Conference Call