DURECT Corporation Presenting at the Adams Harkness & Hill’s 23rd Summer Seminar

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CUPERTINO, Calif., Aug. 5 /PRNewswire-FirstCall/ — DURECT Corporation
(Nasdaq: DRRX) announced today that it will present at the Adams, Harkness &
Hill — 23rd Annual Summer Seminar. The conference is being held at the
Boston Marriott Long Wharf Hotel. James E. Brown, DVM, Chief Executive
Officer, will be presenting at the conference on Wednesday, August 6, 2003 at
2:30 p.m. EDT.

(Logo: http://www.newscom.com/cgi-bin/prnh/20020717/DRRXLOGO )

A live audio webcast of Dr. Brown’s presentation will be available by
accessing DURECT’s homepage at http://www.www.durect.com and clicking “Investor
Relations.”

DURECT Corporation (www.www.durect.com) is pioneering the development and
commercialization of pharmaceutical systems for the treatment of chronic
debilitating diseases and enabling biotechnology-based pharmaceutical
products. DURECT’s goal is to deliver the right drug to the right site in the
right amount at the right time. In addition to its rights to the
CHRONOGESIC(R) product, DURECT owns three proprietary drug delivery platform
technologies, including the SABER(TM) Delivery System (a patented and
versatile depot injectable useful for protein delivery), the MICRODUR(TM)
Biodegradable Microparticulates (microspheres injectable system) and the
DURIN(TM) Biodegradable Implant (drug-loaded implant system).

NOTE: CHRONOGESIC(R), SABER(TM), MICRODUR(TM) and DURIN(TM) are
trademarks of DURECT Corporation.

The statements in this press release regarding DURECT’s products in
development and product development plans, are forward-looking statements
involving risks and uncertainties that can cause actual results to differ
materially from those in such forward-looking statements. Potential risks and
uncertainties include, but are not limited to, DURECT’s ability to complete
the design, development, and manufacturing process development of its
products, manufacture and commercialize its products, obtain product and
manufacturing approvals from regulatory agencies, manage its growth and
expenses, manage relationships with third parties, finance its activities and
operations, as well as marketplace acceptance of DURECT’s products. Further
information regarding these and other risks is included in DURECT’s Annual
Report on Form 10-K for the fiscal year ended December 31, 2002 filed with the
SEC on March 14, 2003, DURECT’s Quarterly Report on Form 10Q and other
periodic reports filed with the SEC under the heading “Factors that may affect
future results.”

CHRONOGESIC is under development by DURECT and has not been submitted or
approved for commercialization by the US Food and Drug Administration or other
health authorities.

SOURCE DURECT Corporation

CONTACT:
Schond L. Greenway
Senior Director
Investor Relations and
Strategic Planning of DURECT Corporation
408-777-1417
or
schond.greenway@durect.com
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Web site: http://www.www.durect.com

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