DURECT Corporation Invites You to Join Its Third Quarter 2003 Conference Call On the Web

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CUPERTINO, Calif., Oct. 20 /PRNewswire-FirstCall/ —
In conjunction with DURECT Corporation’s (Nasdaq: DRRX) third quarter 2003
financial results press release, you are invited to listen to its conference
call that will be broadcast live over the Internet on Thursday, November 6,
2003 at 4:30 p.m. EST with Jim Brown, President and Chief Executive Officer,
Tom Schreck, Chief Financial Officer and Felix Theeuwes, Chairman and Chief
Scientific Officer.

     What:     DURECT Corporation's Third Quarter 2003 Earnings Conference
               Call
     When:     Thursday, November 6th, 2003, 4:30 p.m. EST
     Where:    www.www.durect.com and click "Investor Relations"
               Live over the Internet -- Simply log on to the Web at the
               address listed above.

If you are unable to participate during the live webcast, the call will be
archived on DURECT’s website under Audio Archive in the “Investor Relations”
section.

DURECT Corporation (www.www.durect.com) is pioneering the development and
commercialization of pharmaceutical systems for the treatment of chronic
debilitating diseases and enabling biotechnology-based pharmaceutical
products. DURECT’s goal is to deliver the right drug to the right site in the
right amount at the right time. In addition to its rights to the
CHRONOGESIC(R) product, DURECT owns three proprietary drug delivery platform
technologies, including the SABER(TM) Delivery System (a patented and
versatile depot injectable useful for protein delivery), the MICRODUR(TM)
Biodegradable Microparticulates (microspheres injectable system) and the
DURIN(TM) Biodegradable Implant (drug-loaded implant system).

(Logo: http://www.newscom.com/cgi-bin/prnh/20020717/DRRXLOGO )

NOTE: CHRONOGESIC(R), SABER(TM), MICRODUR(TM) and DURIN(TM) are trademarks
of DURECT Corporation.

SOURCE DURECT Corporation

CONTACT:
Schond L. Greenway
Senior Director, Investor Relations and
Strategic Planning of DURECT Corporation
408-777-1417
/Photo: NewsCom: http://www.newscom.com/cgi-bin/prnh/20020717/DRRXLOGO
AP Archive: http://photoarchive.ap.org
PRN Photo Desk, +1-888-776-6555 or +1-212-782-2840
/Web site: http://www.www.durect.com

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