DURECT Corporation Invites You to Join Its Second Quarter 2004 Conference Call on the Web

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CUPERTINO, Calif., July 15 /PRNewswire-FirstCall/ — In conjunction with
DURECT Corporation’s (Nasdaq: DRRX) second quarter 2004 financial results
press release, you are invited to listen to its conference call that will be
broadcast live over the Internet on Wednesday, July 21, 2004 at 4:30 p.m. EST
with Jim Brown, President and Chief Executive Officer, Tom Schreck, Chief
Financial Officer and Felix Theeuwes, Chairman and Chief Scientific Officer.

What: DURECT Corporation’s First Quarter 2004 Earnings Conference Call

When: Wednesday July 21st, 2004, 4:30 p.m. EST

Where: www.www.durect.com and click ‘Investor Relations’
Live over the Internet — Simply log on to the Web at the address
listed above.

If you are unable to participate during the live webcast, the call will be
archived on DURECT’s website under Audio Archive in the “Investor Relations”

(Logo: http://www.newscom.com/cgi-bin/prnh/20020717/DRRXLOGO )

DURECT Corporation (www.www.durect.com) is pioneering the development and
commercialization of pharmaceutical systems for the treatment of chronic
debilitating diseases and enabling biotechnology-based pharmaceutical
products. DURECT’s goal is to deliver the right drug to the right site in the
right amount at the right time.

The statements in this press release regarding DURECT’s products in
development and product development plans are forward-looking statements
involving risks and uncertainties that can cause actual results to differ
materially from those in such forward-looking statements. Potential risks and
uncertainties include, but are not limited to, DURECT’s abilities to complete
the design, development, and manufacturing process development of its
products, manufacture and commercialize its products, obtain product and
manufacturing approvals from regulatory agencies, manage its growth and
expenses, manage relationships with third parties, finance its activities and
operations, as well as marketplace acceptance of these products. Further
information regarding these and other risks is included in DURECT’s Annual
Report on Form 10-K for the fiscal year ended December 31, 2003 filed with the
SEC on March 11, 2004, DURECT’s Quarterly Report on Form 10Q and other
periodic reports filed with the SEC under the heading “Factors that may affect
future results.”


CONTACT: Schond L. Greenway, Executive Director, IR and Strategic
Planning of DURECT Corporation, +1-408-777-1417/
Web site: http://www.www.durect.com

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