DURECT Corporation to Present at the Security Research Associates’ Spring Technology & Life Sciences Investor Conference

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CUPERTINO, Calif., Feb 24, 2005 /PRNewswire-FirstCall via COMTEX/ — DURECT Corporation
(Nasdaq: DRRX) announced today that it will present at the Security Research
Associates Spring Technology & Life Sciences Investor Conference at the
Campton Place Hotel in San Francisco. Dr. James E. Brown, President and Chief
Executive Officer, will be presenting at the conference on Monday, February
28, 2005 at 11:30 a.m. PST.

(Logo: http://www.newscom.com/cgi-bin/prnh/20020717/DRRXLOGO )

About DURECT Corporation

DURECT Corporation is an emerging specialty pharmaceuticals systems
company focused on the development of pharmaceutical systems based on its
proprietary drug delivery platform technologies that treat chronic
debilitating diseases and enable biotechnology products. These platform
technologies include the SABER(TM) Delivery System (a patented and versatile
depot injectable useful for protein and small molecule delivery), the
ORADUR(TM) sustained release oral gel-cap technology (an oral sustained
release technology with several potential abuse deterrent properties), the
DURIN(TM) Biodegradable Implant (drug-loaded implant system), the TRANSDUR(TM)
transdermal technology and the MICRODUR(TM) Biodegradable Microparticulates
(microspheres injectable system). DURECT also partners with pharmaceutical
companies to develop and commercialize proprietary and enhanced pharmaceutical
products based on its technologies. DURECT has five disclosed on-going
development programs of which three are in collaboration with pharmaceutical
partners. Additional information about DURECT is available at www.www.durect.com.

trademarks of DURECT Corporation. Other referenced trademarks belong to their
respective owners.


Schond L. Greenway (investors), Executive Director, IR and Strategic Planning,
408-777-1417, or
Melissa M. Ta (media), Associate Director, Corporate
Communications, 408-777-1417,
both of DURECT Corporation


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