DURECT Corporation Presenting at Summer Tech Fest 2005 Investor Conference Hosted by C.E. Unterberg Towbin and Security Research Associates

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CUPERTINO, Calif., Aug. 8 /PRNewswire-FirstCall/ — DURECT Corporation
(Nasdaq: DRRX) announced today that it will present at the Summer Tech Fest
2005 Investor Conference Hosted by C.E. Unterberg Towbin and Security Research
Associates. The conference is being held at the Omni Hotel in San Francisco.
Felix Theeuwes, D.Sc., Chairman and Chief Scientific Officer, will be
presenting at the conference on Wednesday, August 10th at 10:45 a.m. Pacific
Daylight Time.

There will be a live webcast of the presentation from the conference. The
webcast will be available on DURECT’s website under the Event Calendar section
of ‘Investor Relations.’ The presentation will also be available for replay on
DURECT’s website for a period of up to 30 days after the conference.

ABOUT DURECT

DURECT Corporation is an emerging specialty pharmaceutical company focused
on the development of pharmaceutical systems based on its proprietary drug
delivery platform technologies that treat chronic debilitating diseases and
enable biotechnology products. These platform technologies include the
SABER(TM) Delivery System (a patented and versatile depot injectable useful
for protein and small molecule delivery), the ORADUR(TM) sustained release
oral gel-cap technology (an oral sustained release technology with several
potential abuse deterrent properties), the DURIN(TM) Biodegradable Implant
(drug-loaded implant system), the TRANSDUR(TM) transdermal technology and the
MICRODUR(TM) Biodegradable Microparticulates (microspheres injectable system).
DURECT also collaborates with pharmaceutical companies to develop and
commercialize proprietary and enhanced pharmaceutical products based on its
technologies. DURECT has five disclosed on-going development programs of which
four are in collaboration with pharmaceutical partners. Additional information
about DURECT is available at www.www.durect.com.

NOTE: SABER(TM), ORADUR(TM), DURIN(TM), TRANSDUR(TM) and MICRODUR(TM) are
trademarks of DURECT Corporation. Other referenced trademarks belong to their
respective owners.

SOURCE DURECT Corporation

08/08/2005

/CONTACT: Schond L. Greenway, Executive Director, IR and Strategic
Planning of DURECT Corporation, +1-408-777-1417/

/Web site: http://www.www.durect.com /

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