DURECT Corporation Invites You to Join Its Third Quarter 2005 Conference Call on the Web

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CUPERTINO, Calif., Oct 07, 2005 /PRNewswire-FirstCall via COMTEX News Network/ — In conjunction with
DURECT Corporation’s (Nasdaq: DRRX) third quarter 2005 financial results press
release, you are invited to listen to its conference call that will be
broadcast live over the Internet on Thursday, October 13, 2005 at 4:30 p.m.

What: DURECT Corporation’s Third Quarter 2005 Earnings Conference Call

When: Thursday October 13th, 2005, 4:30 p.m. EDT (1:30 p.m. PDT)

Where: www.www.durect.com and click ‘Investor Relations’

Live over the Internet — Simply log on to the Web at the address listed

If you are unable to participate during the live webcast, the call will be
archived on DURECT’s website under Audio Archive in the “Investor Relations”

About DURECT Corporation

DURECT Corporation is an emerging specialty pharmaceutical company focused
on the development of pharmaceutical systems based on its proprietary drug
delivery platform technologies that treat chronic or episodic diseases and
enable biotechnology products. These platform technologies include the
SABER(TM) Delivery System (a patented and versatile depot injectable useful
for protein and small molecule delivery), the ORADUR(TM) sustained release
oral gel-cap technology (an oral sustained release technology with several
potential abuse deterrent properties), the DURIN(TM) Biodegradable Implant
(drug-loaded implant system), the TRANSDUR(TM) transdermal technology and the
MICRODUR(TM) Biodegradable Microparticulates (microspheres injectable system).
DURECT also collaborates with pharmaceutical companies to develop and
commercialize proprietary and enhanced pharmaceutical products based on its
technologies. DURECT has five disclosed on-going development programs of which
four are in collaboration with pharmaceutical partners. Additional information
about DURECT is available at www.www.durect.com.

trademarks of DURECT Corporation. Other referenced trademarks belong to their
respective owners.


Schond L. Greenway, Executive Director, Investor Relations and Strategic Planning of
DURECT Corporation, +1-408-777-1417

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