DURECT Highlights Major Commercial Strategic Alliance for ORADUR(TM) Sustained Release Oral Gel-cap Technology

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CUPERTINO, Calif., Nov. 11 /PRNewswire-FirstCall/ — DURECT Corporation
(Nasdaq: DRRX) announced the validation of the commercial potential of its
ORADUR(TM) sustained release oral gel-cap technology with the recently
announced strategic alliance to develop and commercialize Remoxy(TM), an
ORADUR-based novel long-acting, abuse-deterrent oral formulation of oxycodone
and other ORADUR-based products candidates using three other opioid drugs. On
November 10, 2005, King Pharmaceuticals, Inc. and Pain Therapeutics, Inc.
announced that the companies have entered into a strategic alliance to develop
and commercialize Remoxy and other ORADUR-based abuse-deterrent products using
three other opioid drugs.

(Logo: http://www.newscom.com/cgi-bin/prnh/20020717/DRRXLOGO )

“We are very pleased to have King Pharmaceuticals endorse the commercial
potential for products based on our ORADUR platform technology. We are excited
to have a strong commercial organization such as King Pharmaceuticals
responsible for the commercialization of these products. This collaboration is
just one example of pharmaceutical companies looking for unique products based
on novel, patented technology platforms such as ours to address large and
growing unmet medical needs,” stated James E. Brown, DVM, President and Chief
Executive Officer.

“We look forward to working with King and Pain Therapeutics to bring
Remoxy and these other long-acting opioid drugs to the marketplace and
generating significant value from these products for our shareholders.
Furthermore, we look forward to developing additional innovative sustained
release oral gel-cap products that utilize other opioids and other active
agents prone to abuse.”

“King is highly committed to making Remoxy and the three follow-on
ORADUR-opioid products a commercial success. We believe that this represents a
great market opportunity based upon the unmet medical need for narcotics with
reduced abuse potential,” stated Brian Markison, President and Chief Executive
Officer of King Pharmaceuticals, Inc.


ORADUR sustained released oral gel-cap technology provides the unique
characteristics of Remoxy and the referenced follow-on products. Products
based on the ORADUR technology can take the form of an easy to swallow gelatin
capsule that uses a high-viscosity base component, SABER(TM), to provide
controlled release of active ingredients for a period of from 12 to 24 hours
of drug delivery. Oral dosage forms based on the ORADUR gel-cap may also have
the added benefit of being less prone to abuse than other controlled release
dosage forms on the market today. ORADUR-based products can be manufactured by
a simple process using conventional methods making them readily scalable.
These properties have the potential to make ORADUR-based products an
attractive option for pharmaceutical companies that seek to develop tamper and
abuse resistant oral products.

About Remoxy

Remoxy is an oral, long-acting oxycodone capsule under development by Pain
Therapeutics, Inc. that incorporates several abuse-deterrent properties and
offers the convenience of twice-a-day dosing. Remoxy is formulated with DURECT
Corporation’s ORADUR technology under a joint development and license
agreement. Under the terms of the license agreement between Pain Therapeutics
and DURECT, Pain Therapeutics has exclusive worldwide rights to develop and to
commercialize Remoxy and other ORADUR-based products using three other opioid
drugs. DURECT is reimbursed for formulation and other work performed under its
agreement with Pain Therapeutics, and will receive milestone payments based on
the achievement of certain technical, clinical or regulatory milestones, in
addition to receiving royalties on end product sales. Oxycodone is also the
active drug ingredient in OxyContin(R), the leading brand name opioid used in
the treatment of moderate-to-severe pain, with U.S. sales of nearly $2 billion
for the 12-months ending August 2005, according to IMS Health data. Oxycodone
is also the active drug ingredient in Remoxy and in the branded product
OxyContin(R). Drug abusers can easily extract oxycodone from OxyContin(R)
tablets in order to induce a quick and powerful euphoric high. Oxycodone
abusers risk respiratory depression, which can be fatal, and opioid addiction.

Remoxy – Phase III Clinical Program

Pain Therapeutics is currently designing a pivotal Phase III study with
Remoxy in patients with severe chronic pain. According to Pain Therapeutics,
the trial is expected to begin in January 2006.

About DURECT Corporation

DURECT Corporation is an emerging specialty pharmaceutical company focused
on the development of pharmaceutical systems based on its proprietary drug
delivery platform technologies that treat chronic debilitating diseases and
enable biotechnology products. These platform technologies include the
SABER(TM) Delivery System (a patented and versatile depot injectable useful
for protein and small molecule delivery), the ORADUR(TM) sustained release
oral gel-cap technology (an oral sustained release technology with several
potential abuse deterrent properties), the DURIN(TM) Biodegradable Implant
(drug-loaded implant system), the TRANSDUR(TM) transdermal technology and the
MICRODUR(TM) Biodegradable Microparticulates (microspheres injectable system).
DURECT also collaborates with pharmaceutical companies to develop and
commercialize proprietary and enhanced pharmaceutical products based on its
technologies. DURECT has five disclosed on-going development programs of which
four are in collaboration with pharmaceutical partners. Additional information
about DURECT is available at www.www.durect.com.

trademarks of DURECT Corporation. Other referenced trademarks belong to their
respective owners.

DURECT Forward-Looking Statement

The statements in this press release regarding DURECT’s and its
collaborative partners’ products in development, anticipated product benefits,
and clinical trial results and plans are forward-looking statements involving
risks and uncertainties that can cause actual results to differ materially
from those in such forward-looking statements. Potential risks and
uncertainties include, but are not limited to, DURECT’s (and that of its
third-party collaborators’, where applicable) abilities to successfully enroll
and complete clinical trials, complete the design, development, and
manufacturing process development of the product candidate, obtain product and
manufacturing approvals from regulatory agencies and manufacture and
commercialize the product candidate, as well as marketplace acceptance of the
product candidate. Further information regarding these and other risks is
included in DURECT’s Quarterly Report on Form 10-Q for the quarter ended
September 30, 2005 filed with the SEC on October 13, 2005 under the heading
“Factors that may affect future results.”

SOURCE  DURECT Corporation
    -0-                             11/11/2005
    /CONTACT:  Schond L. Greenway, Executive Director, Investor Relations and
Strategic Planning of DURECT Corporation, +1-408-777-1417/
    /Photo:  NewsCom:  http://www.newscom.com/cgi-bin/prnh/20020717/DRRXLOGO
             AP Archive:  http://photoarchive.ap.org
             PRN Photo Desk, photodesk@prnewswire.com/
    /Web site:  http://www.www.durect.com /

CO:  DURECT Corporation; King Pharmaceuticals, Inc.; Pain Therapeutics, Inc.
ST:  California

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2399 11/11/2005 06:30 EST http://www.prnewswire.com
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