DURECT Corporation Invites You to Join Its Fourth Quarter and Year-End 2005 Conference Call on the Web

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CUPERTINO, Calif., Jan. 23 /PRNewswire-FirstCall/ — In conjunction with
DURECT Corporation’s (Nasdaq: DRRX) fourth quarter and year-end 2005 financial
results press release, you are invited to listen to its conference call that
will be broadcast live over the Internet on Wednesday, February 8th, 2006 at
4:30 p.m. EST.

(Logo: http://www.newscom.com/cgi-bin/prnh/20020717/DRRXLOGO )

What: DURECT Corporation’s Fourth Quarter and Year-End 2005 Earnings
Conference Call
When: Wednesday, February 8th, 2006, 4:30 p.m. EST (1:30 p.m. PST)
Where: www.www.durect.com and click “Investor Relations”
Live over the Internet — Simply log on to the Web at the address
listed above.

If you are unable to participate during the live webcast, the call will be
archived on DURECT’s website under Audio Archive in the “Investor Relations”

About DURECT Corporation

DURECT Corporation is an emerging specialty pharmaceutical company focused
on the development of pharmaceutical systems based on its proprietary drug
delivery platform technologies. The company is developing pharmaceutical
systems to deliver the right drug to the right place in the right amount at
the right time to treat chronic and episodic diseases and conditions.

DURECT Corporation

Schond L. Greenway, Vice President, Investor Relations and
Strategic Planning of DURECT Corporation, +1-408-777-1417
Photo: NewsCom: http://www.newscom.com/cgi-bin/prnh/20020717/DRRXLOGO
AP Archive: http://photoarchive.ap.org
PRN Photo Desk, photodesk@prnewswire.com
Web site: http://www.www.durect.com

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