DURECT Corporation Presenting at the BIO CEO and Investor Conference

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CUPERTINO, Calif., Feb. 10 /PRNewswire-FirstCall/ — DURECT Corporation
(Nasdaq: DRRX) announced today that it will present at the BIO CEO Investor
Conference. The conference is being held at The Waldorf Hotel in New York, NY.
Schond L. Greenway, Vice President, Investor Relations and Strategic Planning,
will be presenting at the conference on February 15, 2006 at 1:00 p.m. Eastern
Standard Time (10:00 a.m. Pacific Standard Time).

(Photo: NewsCom: http://www.newscom.com/cgi-bin/prnh/20020717/DRRXLOGO )

A live audio webcast of the presentation will be available by accessing
DURECT’s homepage at http://www.www.durect.com and clicking “Investor Relations.”

About DURECT Corporation

DURECT Corporation is an emerging specialty pharmaceutical company focused
on the development of pharmaceutical systems based on its proprietary drug
delivery platform technologies. The company is developing pharmaceutical
systems to deliver the right drug to the right place in the right amount at
the right time to treat chronic and episodic diseases and conditions.

SOURCE DURECT Corporation

CONTACT: Schond L. Greenway, Vice President, Investor Relations and
Strategic Planning of DURECT Corporation, +1-408-777-1417

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