DURECT Corporation Invites You to Join Its First Quarter 2006 Conference Call on the Web

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CUPERTINO, Calif., April 25, 2006 /PRNewswire-FirstCall via COMTEX News Network/ — In conjunction with
DURECT Corporation’s (Nasdaq: DRRX) first quarter 2006 financial results press
release, you are invited to listen to its conference call that will be
broadcast live over the Internet on Tuesday, May 2nd, 2006 at 4:30 p.m. EDT.

(Logo: NewsCom: http://www.newscom.com/cgi-bin/prnh/20020717/DRRXLOGO )

What: DURECT Corporation’s First Quarter 2006 Earnings Conference Call
When: Tuesday, May 2nd, 2006, 4:30 p.m. EDT (1:30 p.m. PDT)
Where: www.www.durect.com and click ‘Investor Relations’
Live over the Internet — Simply log on to the Web at the address
listed above.

If you are unable to participate during the live webcast, the call will be
archived on DURECT’s website under Audio Archive in the “Investor Relations”

About DURECT Corporation

DURECT Corporation is an emerging specialty pharmaceutical company focused
on the development of pharmaceutical systems based on its proprietary drug
delivery platform technologies. The company is developing pharmaceutical
systems to deliver the right drug to the right place in the right amount at
the right time to treat chronic and episodic diseases and conditions.

DURECT Corporation

Schond L. Greenway, Vice President, Investor Relations and Strategic Planning of
DURECT Corporation, +1-408-777-1417

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