DURECT Corporation Invites You to Join Its Second Quarter 2007 Earnings Conference Call on the Web

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CUPERTINO, Calif., July 31, 2007 /PRNewswire-FirstCall via COMTEX News Network/ — In conjunction with
DURECT Corporation’s (Nasdaq: DRRX) second quarter 2007 financial results
press release, you are invited to listen to the conference call that will be
broadcast live over the Internet on Tuesday, August 7th 2007 at 4:30 p.m. EDT.

(Logo: http://www.newscom.com/cgi-bin/prnh/20020717/DRRXLOGO )

A live audio webcast of the presentation will be available by accessing
DURECT’s homepage at www.www.durect.com and clicking “Investor Relations.” If you
are unable to participate during the live webcast, the call will be archived
on DURECT’s website under Audio Archive in the “Investor Relations” section.

What: DURECT Corporation’s First Quarter 2007 Earnings Conference Call

When: Tuesday, August 7th, 2007, 4:30 p.m. EDT (1:30 p.m. PDT)

Where: www.www.durect.com and click ‘Investor Relations’ Live over the
Internet – Simply log on to the Web at the address listed above.

About DURECT Corporation

DURECT Corporation is an emerging specialty pharmaceutical company
developing pharmaceutical systems based on its proprietary drug delivery
platform technologies. The Company currently has a number of late-stage
pharmaceutical products in development addressing large markets in pain
management, with a number of research programs underway targeting chronic
disease and other therapeutic areas. For more information, please visit


Matthew J. Hogan, Chief Financial Officer, +1-408-777-4936, or media, Jeremiah Hall
of Feinstein Kean Healthcare, Senior Vice President, +1-415 677-2700,


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