DURECT to Present at Upcoming Conferences

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CUPERTINO, Calif., Dec. 4 /PRNewswire-FirstCall/ — DURECT Corporation
(Nasdaq: DRRX) announced today that it will present a corporate overview and
update at two upcoming life sciences conferences in New York, NY.

    (Logo: http://www.newscom.com/cgi-bin/prnh/20020717/DRRXLOGO)

    --  NYSSA Biotech & Specialty Pharmaceuticals Industry Conference on
        Tuesday, December 11, 2007 at The New York Society of Security
        Analysts at 10:20 a.m. EST.
    --  RBC Capital Markets Healthcare Conference on Wednesday, December 12,
        2007 at the Westin Times Square Hotel at 11:00 a.m. EST.

A live audio webcast of the presentations will be available by accessing
DURECT’s homepage at http://www.www.durect.com and clicking “Investor Relations”.
If you are unable to participate during the live webcast, the call will be
archived on DURECT’s website under Audio Archive in the “Investor Relations”

About DURECT Corporation

DURECT Corporation is an emerging specialty pharmaceutical company
developing pharmaceutical systems based on its proprietary drug delivery
platform technologies. The Company currently has a number of late-stage
pharmaceutical products in development addressing large markets in pain
management, with a number of research programs underway targeting chronic
disease and other therapeutic areas. For more information, please visit

SOURCE  DURECT Corporation
    -0-                             12/04/2007
    /CONTACT:  Matthew J. Hogan, Chief Financial Officer of DURECT
Corporation, +1-408-777-4936/
    /Photo:  NewsCom:  http://www.newscom.com/cgi-bin/prnh/20020717/DRRXLOGO
              AP Archive:  http://photoarchive.ap.org
              PRN Photo Desk, photodesk@prnewswire.com/
    /Web site:  http://www.www.durect.com/

CO:  DURECT Corporation
ST:  California

-- AQTU156 --
6805 12/04/2007 08:50 EST http://www.prnewswire.com
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