Unlocking the potential of epigenetic therapeutics to revolutionize medicine
DURECT harnesses epigenetic regulation to treat acute and chronic organ injury. Our unique approach has the potential to change the course of disease and improve patients’ lives.
Epigenetic Regulation
Alcohol-Associated Hepatitis (AH)
Clinical Trials
We are currently conducting a Phase 2b study (AHFIRM) in subjects with Alcohol-Associated Hepatitis (AH) in more than 60 clinical trial sites across the US, EU, UK, and Australia.


Partner with us
We welcome strategic partnerships to advance our collective goal to meaningfully impact patients’ lives and offer better therapeutic options.
Careers
Join our highly experienced, talented, and collaborative team as we strive to improve the course of human medicine with novel epigenetic therapies.


Press Releases
DURECT Corporation Announces Appointment of Gail Maderis as Chair of the Board
Mar 21, 2023, 16:30 ET CUPERTINO, Calif., March 21, 2023 /PRNewswire/ — DURECT Corporation (Nasdaq: DRRX) announced today that Gail Maderis has assumed the role
DURECT Corporation Fireside Chat at the Oppenheimer 33rd Annual Healthcare Conference
Mar 09, 2023, 08:30 ET CUPERTINO, Calif., March 9, 2023 /PRNewswire/ — DURECT Corporation (Nasdaq: DRRX) today announced that Dr. James Brown, President and CEO
References
- Argemi J, Latasa MU, Atkinson SR, et al. Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis. Nat Commun. 2019;10(1):3126. doi:10.1038/s41467-019-11004-3
- Mazzone R, Zwergel C, Artico M, et al. The emerging role of epigenetics in human autoimmune disorders. Clin Epigenetics. 2019;11(1):34. doi:10.1186/s13148-019-0632-2
- Herman A, Occean JR, Sen P. Epigenetic dysregulation in cardiovascular aging and disease. J Cardiovasc Aging. 2021;1:10. doi:10.20517/jca.2021.16
- Hassanein T, Stein L, Flamm S, et al. Safety and efficacy of DUR-928: A potential new therapy for acute alcoholic hepatitis. Late-breaking oral presentation at AASLD The Liver Meeting®; 2019 November 12.